University of California System: University of California, San Francisco(x)
University of California, San Francisco
29 Innovations found
| A Synthetic Module and Method for Silencing Gene Expression by Targeting Specific Regions of the Chromosome |
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A system for targeting and tuning heterochromatin has been developed by UCSF investigators. This method allows for inducible and specific silencing of target regions of the chromosome. This is a ...
| Potent Dominant Negative Transcriptional Inhibitors |
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BACKGROUND: The regulation of gene expression by transcription factors is a fundamental aspect of the physiology of all cells. The aberrant expression of transcription factors can lead to abnorma...
| VOLUME-LIMITING CEREBRAL SPINAL FLUID DRAINAGE DEVICE |
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BACKGROUND: Lumbar and ventricular drains are commonly used to solve a variety of medical problems, including, most prominently, to reduce pressure on the brain caused by the excessive build up of...
| Acellular Graft for Bladder or Ureter Regeneration |
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An acellular matrix graft to repair damaged ureter, urethra or bladder using has been developed by UCSF inventors. It can be derived from the ureter, urethra or bladder of human, pig, dog, hamster...
| New Target for Parkinson’s Disease |
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A new pathway implicated in neuronal cell death and Parkinson’s disease has been discovered by UCSF researchers. Use of this pathway could lead to new drug targets and screens for compounds with d...
| Improved Plaque and Prion Neurodegenerative Disease Therapies |
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With the high incidence of protein aggregation-related neurodegenerative diseases like AD and PD in elderly populations, and occasional instances of prion disease outbreaks seriously threatening th...
| Biologic Sling for Treating Pelvic Organ Prolapse and Urinary Incontinence |
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UCSF inventors have developed the methods and composition to isolate, prepare and use an off-the-shelf, non-antigenic biological material of sufficient strength to support organs involved in pelvic...
| Novel miRNA Antagonist of p53 |
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BACKGROUND: The p53 tumor suppressor pathway is well established as a key regulator of cell proliferation, cell death and apoptosis. Most human tumors have found ways to escape the regulation of ...
| Novel Method to Detect, Manipulate, and Isolate Distinct Protein Conformations |
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Background: The activity of virtually every protein class is regulated by altering the protein’s conformational state. For example, metabolic enzymes are regulated by the reversible binding of smal...
| Methods for Inducing Immune Tolerance Using Anti-CD3 therapeutics |
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BACKGROUND: Many treatments for autoimmune disease and transplantation rejection cause non-specific inhibition of the immune system (immunosuppression), which can lead to side effects and also has ...
