Antineoplastic Agents 571. Total Synthesis of Bacillistatins 1 and 2

Arizona State University (AzTE)
posted on 10/08/2009

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Invention Description
The cyclodepsipeptides, bacillistatins 1 and 2, possess potent anti-microbial and anti-neoplastic actions. The need for novel antibotics, given the problems with resistance to conventional drugs, is obvious. Anti-microbial drug resistance is the largest human health care problem facing populations worldwide today.
Researchers at Arizona State University have discovered and developed a synthesis method for two novel cyclodepspeptide compounds. bacillistatin 1 & 2, depicted in the attached file, display antibiotic properties against Streptococcus pneumoniae and S. pyogenes in addition to impressive inhibitory effects against a human cancer cell-line panel.
Benefits and

• Anti-cancer agent
• Antibacterial agent against antibiotic resistant strains

• Synthesis – a method for synthesizing bacillistatin 1 & 2 has been developed and pharmaceutical salts are easily recovered at respectable yields.