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New Use of Inhibitors to Treat Cancer
Brigham and Women's Hospital
posted on 05/12/2011
Technology: Inventors have identified novel mutations in the human Notch1 receptor that lead to uncontrolled cellular growth. Human cancer cells bearing these mutations respond positively to treatment with gamma-secretase inhibitors that interfere with Notch1 activation. Application: Therapeutic - Use of gamma-secretase inhibitors to treat Tcell acute lymphoblastic leukaemia (T-ALL). Companion Diagnostic - Identification of responders versus non-responders for therapy with gamma-secretase inhibitors. Advantages: - Identification of mutations will allow early diagnosis of cancer. - Targeted therapy to patients harboring the Notch1 mutation will improve outcomes and reduce side effects. - Gamma-secretase inhibitors are already under development for Alzheimers disease, hence these could be repurposed for the cancer indication.
File Number: 11026
Other Information: *Investigator(s)*
Adolfo Stephen C.; Ferrando Thomas A.; Blacklow Jon C.; Look Andrew ; Aster Weng
*Contact*
Amita Joshi, 617-954-9526
This innovation currently is not available for online licensing. Please contact Mary Auge at Brigham and Women's Hospital for more information.
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