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Using Selection to Define Rules for Small Molecule Targeting of RNA
University at Buffalo - The State University of New York
posted on 10/20/2009
Information needed to design nucleic acid-based compounds which target RNA can be as limited as knowing the Watson-Crick base pairing "code". However, to date, the clinical success of such compounds (e.g. antisense and RNAi) has been elusive. Unlike nucleic acid-based drug candidates, delivery and stability of small molecules is not as significant an issue, making them more likely to progress through the development path, but designing them to target RNA is far more complicated due to the lack of a chemical "code" for recognition binding of RNA. RNArray is an enabling technology that provides a means for identifying RNA structural motifs which bind to specific organic ligands, thereby establishing a chemical "code" that can be used to search an intended RNA for targetable structural motifs and for the design of small molecule drugs that target such structures. Unlike SELEX
Detailed Description
File Number: 6129
Other Information: Principal Investigator: Matthew Disney
This innovation currently is not available for online licensing. Please contact Tim Dee at University at Buffalo - The State University of New York for more information.
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