Peptides that bind EphB receptors, disrupting receptor-ligand interactions, to modulate the activity of EphB receptors and stimulate apoptosis.

Background

The Eph receptors are a large family of receptor tyrosine kinases that regulate a multitude of biological processes in developing, as well as adult, tissues by binding a family of ligands called ephrins. The Eph receptors are differentially expressed in a variety of healthy tissues and have been implicated in a variety of aspects of normal functions, such as pain processing, platelet aggregation, neuronal development, cell migration and adhesion. The Eph receptors have also been implicated in a variety of pathological processes, including tumor progression, pathological forms of angiogenesis, chronic pain following tissue damage, inhibition of nerve regeneration after spinal cord injury, and human congenital malformations. Furthermore, these receptors have been reported to play a role in the balance of stem cell self-renewal versus cell-fate determination and differentiation. The current invention provides peptides that modulate EphB receptors.

Lead Inventor

Elena Pasquale, Ph.D.

Pasquale lab homepage

Selected References

J Biol Chem. 2002 Dec 6;277(49):46974-9. Koolpe M, Dail M, Pasquale EB.

Patent Information

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Full title: EphB Receptor-binding Peptides

U.S. Patent/Application #: 7,582,438

Priority date: 1-27-2005

Foreign filing: yes

Burnham ID: 05-021

Status

Available for license