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Combination of Local Gene Therapy and Stem Cell Mobilization
Caritas St. Elizabeth's Medical Center
posted on 02/13/2009
Description: Dr. Losordo has discovered that heart and related disorders can be prevented or treated by administering a therapeutically effective amount of at least one nucleic acid that encodes at least one morphogen. The invention further provides for administration of at least one of the endothelial cells (Ecs) and endothelial progenitor cells (EPCs) which is believed to assist practice of the invention in certain settings. It has been found that administration of morphogen according to the invention facilitates a downstream cascade of one or more desirable trophic factors which can help the severity of or in some cases eliminate the disorders. The invention has been demonstrated in several animal models.
File Number: CSEMC-013
Other Information:
Investigator(s)
Douglas Losordo
Contact
Todd Keiller, fax 508/497-0733
This innovation currently is not available for online licensing. Please contact Abi Barrow at Caritas St. Elizabeth's Medical Center for more information.
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