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Inhibition of Src for MI
Caritas St. Elizabeth's Medical Center
posted on 02/13/2009
Description: During myocardial infarction the entire myocardium experiences decreased flow due in part to edema resulting in response to the onset of ischemic injury. Similarly the ischemia/reperfusion of percutaneous and surgical revascularization procedures is known to cause myocardial injury. Our studies have shown that inhibition of Src significantly reduces myocardial injury, thus enhancing recovery from myocardial infarction and revascularization procedures. This approach could be used for treatment of all ischemic chest pain including myocardial infarction, unstable angina. It also could be used prophylactically in all coronary revascularization procedures inlcluding percutaneous (angioplasty, stent, atherectomy, cutting balloon, drug eluting stent, rotational atherectomy, etc) and surgical (bypass).
File Number: CSEMC-014
Other Information:
Investigator(s)
Douglas Losordo
Contact
Todd Keiller, fax 508/497-0733
This innovation currently is not available for online licensing. Please contact Abi Barrow at Caritas St. Elizabeth's Medical Center for more information.
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