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Assay to Detect Hepcidin
Children's Hospital Boston
posted on 08/31/2011
Hepcidin is the master regulatory signal for iron homeostasis. Hepcidin is a small peptide with several different forms, some active and others inactive precursors or breakdown products. Elevated hepcidin is associated with anemia resulting from many conditions; decreased hepcidin can lead to iron overload. Although measurement of hepcidin is not yet a standard parameter in clinical diagnostics, many think it will become a valuable measure of iron status in a wide number of iron-related diseases. || Mass spectrometry is ideal for measurement of hepcidin (able to detect small peptides, reliable quantification, and excellent ability to distinguish different forms). Children's investigators have developed a method for MALDI-TOF detection of hepcidin using a 384-spot MALDI target chip that has the ability to concentrate and enrich the hepcidin from blood, plasma, serum or urine samples. Hepcidin is detected in a single analytic step with minimal sample pre-processing, allowing rapid processing of samples in parallel for high throughput.
File Number: CMCC 1535
Other Information: *Investigator(s)*
Hanno Steen
*Contact*
Connie Caron, Connie.Caron@childrens.harvard.edu
This innovation currently is not available for online licensing. Please contact David Altman at Children's Hospital Boston for more information.
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