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Modulators of Nitric Oxide Signaling for the Stimulation Hematopoietic Stem Cells
Children's Hospital Boston
posted on 07/01/2010
Dr. Zon's Lab has discovered that nitric oxide (NO) signaling is a conserved regulator of hematopoietic stem cell (HSC) development. During embryogenesis in both zebafish and mammals, the initial generation of blood flow is required in order to induce a NO-mediated stimulation of HSC proliferation and differentiation. Screening for chemical modulators of HSC proliferation, the Zon lab as discovered that compounds that stimulate NO generation or NO pathway response can enhance the proliferation of HSCs. This work provides a platform for the identification and testing of compounds for the stimulation of HSC proliferation and engraftment. Initial chemical hits provide leads for the development of novel therapeutics and new uses for existing pharmaceutics for HCS transplants.
File Number: CMCC 1720
Other Information: *Investigator(s)*
Leonard I Zon
*Contact*
Abbie Meyer, Abbie.Meyer@childrens.harvard.edu
This innovation currently is not available for online licensing. Please contact David Altman at Children's Hospital Boston for more information.
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