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Novel peptides to promote wound healing and neuroprotection
Children's Hospital Boston
posted on 04/29/2010
Drs. D'Amato and Adini tested synthetic short peptides from a well-known membrane bound protein. They found that a 12-mer peptide derived from the extracellular domain was able to dramatically stimulate VEGF binding to endothelial cells, to enhance cell proliferation in vitro, and cell migration and angiogenesis in vivo. This peptide promoted wound healing by 50% over control in the diabetic mouse wound healing model. Interestingly, the peptide also increased neurite outgrowth in primary cortical neuronal cells. Drs. D'Amato and Adini are currently exploring various peptide designs to further optimize activity and are expanding testing to other in vivo models of wound healing and neurodegeneration.
File Number: CMCC 1691
Other Information: *Investigator(s)*
Robert D'Amato
*Contact*
Maude Tessier, Maude.Tessier@childrens.harvard.edu
This innovation currently is not available for online licensing. Please contact David Altman at Children's Hospital Boston for more information.
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