Thermal Stability Assay for Glaucoma-Causing Myocilin Mutants and Method to Screen for Small Molecule Stabilizers

Georgia Tech Research Corporation
posted on 09/01/2010

Myocilin is a protein closely linked to autosomal-dominant inherited forms of primary open angle glaucoma, a prevalent neurodegenerative disorder characterized by increased intraocular pressure. Ga Tech researchers have developed a novel thermal stability assay for the identification of small molecules that could be potential treatments for primary open angle glaucoma. This assay identifies small molecules that stabilize mutant myocilin and promote secretion to the extracelluar matrix which may result in a reduction of intraocular pressure and ultimately the delay of onset of glaucoma.

Suggested Uses

identification of small molecules for treatment of glaucoma

Advantages

first assay to identify therapeutics for glaucoma based on stabilizing effect of caustive proteins

Detailed Description

Myocilin is a protein closely linked to autosomal-dominant inherited forms of primary open angle glaucoma, a prevalent neurodegenerative disorder characterized by increased intraocular pressure. Ga Tech researchers have developed a novel thermal stability assay for the identification of small molecules that could be potential treatments for primary open angle glaucoma. This assay identifies small molecules that stabilize mutant myocilin and promote secretion to the extracelluar matrix which may result in a reduction of intraocular pressure and ultimately the delay of onset of glaucoma.

File Number: GTRC ID 5021

Web site: http://www.chemistry.gatech.edu/faculty/Lieberman/

Disease: Ophthalmology and Optometry

This innovation currently is not available for online licensing. Please contact Marie-Christine Reames at Georgia Tech Research Corporation for more information.

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Thermal Stability Assay for Glaucoma-Causing Myocilin Mutants and Method to Screen for Small Molecule Stabilizers

Linda L. Restifo, M.D., Ph.D. - University of Arizona