Blood-brain barrier
The blood-brain barrier (BBB) is a separation of circulating blood and cerebrospinal fluid (CSF) maintained by the choroid plexus in the central nervous system (CNS)... Overcoming the difficulty of delivering therapeutic agents to specific regions of the brain presents a major challenge to treatment of most brain disorders. In its neuroprotective role, the blood-brain barrier functions to hinder the delivery of many potentially important diagnostic and therapeutic agents to the brain. Therapeutic molecules and genes that might otherwise be effective in diagnosis and therapy do not cross the BBB in adequate amounts. - Wikipedia
| UCSD TTO 10 SEP 10 |
Novel Inhibitors of Trypanosoma Brucei UDP-Galactose 4'-Epimerase (TbGaIE) The parasitic protist Trypanosoma brucei , the causative agent of human African trypanosomiasis ( HAT , or sleeping sickness), currently affects between 50,000 and 70,000 individuals in Africa. Transmitted by the tsetse fly, this disease is endemic in regions of sub-Saharan Africa, impactin... |
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| UNeMed 24 AUG 10 |
Method to Inhibit Reperfusion Injury in Cerebral Stroke Reperfusions can lead to severe damage in patients with heart attacks and strokes, the SOD -nanoparticles would be highly beneficial for use in hospitals for treating these patients. |
| UNeMed 23 AUG 10 |
Polymer-Protein Compositions for CNS Delivery This drug delivery technology has the potential to treat neurodegenerative disorders like Alzheimer’s Disease or Parkinson’s Disease, as well as neuroinflammation and stroke. |
| University of Minnesota 12 JUL 10 |
Cancer Vaccine with CpG and Lysate for Glioblastoma A cancer vaccine composed of CpG and glioma cell lysate has the ability to treat and cure drug resistant glioblastoma tumors. Glioma tumors are lethal and carry a very short survival time. This new cancer vaccine elicits an anti-tumor immune response to kill these brain tumors. This vaccine has ... |
| Harvard University OTD 09 JUL 10 |
Novel pain therapeutics to improve tolerance and activity MARKETS ADDRESSED : Morphine and other opioids are used as analgesics for relief from severe pain associated with cancer and surgical operations. The world wide market size for opioids is estimated at $9.6B in 2008, with a projected market value at $11.9B in 2018. Although morphine is widely ... |
| Harvard University OTD 09 JUL 10 |
Portfolio of Novel Monoamine Uptake Inhibitors Targeting Monoamine Transporters MARKETS ADDRESSED : Monoamine transporters are principal targets of widely used therapeutic agents to treat depression, attention deficit hyperactivity disorder, narcolepsy, obsessive-compulsive disorders, anxiety disorders, nicotine addiction, autism and others. Compounds of this class are a... |
| University of Michigan 05 JUN 10 |
A Drug Delivery Composition for Brain Tumor Treatment A Drug Delivery Composition for Brain Tumor Treatment |
| Columbia Tech Ventures 04 JUN 10 |
Lead Inventor: Andreas H. Kottmann, Ph.D. Tech Ventures Reference: IR 2515, 2518 Problem or Unmet Need: Glial cell-derived neurotrophic factor (GDNF) is a target-secreted neuroprotective, neurotrophic, and... |
| UC Irvine 04 JUN 10 |
Researchers at the University of California have been using in vitro experiments and a mouse model to investigate cell based therapies for the treatment of central nervous system ( CNS ) and spinal cord injuries. |
| UCLA 23 MAY 10 |
Pharmacological Stroke Therapy To Promote Neural Repair And Axonal Sprouting Injuries to the brain or spinal cord from stroke, trauma or neurodegenerative disease produce a limited reparative response and minimal functional recovery. Current treatment for such injuries is limited to physical rehabilitation and acute intravenous administration of a thrombolytic drug cal... |
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