Novel Inhibitors of Trypanosoma Brucei UDP-Galactose 4'-Epimerase (TbGaIE)

The parasitic protist Trypanosoma brucei , the causative agent of human African trypanosomiasis ( HAT , or sleeping sickness), currently affects between 50,000 and 70,000 individuals in Africa. Transmitted by the tsetse fly, this disease is endemic in regions of sub-Saharan Africa, impactin...

Method to Inhibit Reperfusion Injury in Cerebral Stroke

Reperfusions can lead to severe damage in patients with heart attacks and strokes, the SOD -nanoparticles would be highly beneficial for use in hospitals for treating these patients.

Polymer-Protein Compositions for CNS Delivery

This drug delivery technology has the potential to treat neurodegenerative disorders like Alzheimer’s Disease or Parkinson’s Disease, as well as neuroinflammation and stroke.

Cancer Vaccine with CpG and Lysate for Glioblastoma

A cancer vaccine composed of CpG and glioma cell lysate has the ability to treat and cure drug resistant glioblastoma tumors. Glioma tumors are lethal and carry a very short survival time. This new cancer vaccine elicits an anti-tumor immune response to kill these brain tumors. This vaccine has ...

Novel pain therapeutics to improve tolerance and activity

MARKETS ADDRESSED : Morphine and other opioids are used as analgesics for relief from severe pain associated with cancer and surgical operations. The world wide market size for opioids is estimated at $9.6B in 2008, with a projected market value at $11.9B in 2018. Although morphine is widely ...

Portfolio of Novel Monoamine Uptake Inhibitors Targeting Monoamine Transporters

MARKETS ADDRESSED : Monoamine transporters are principal targets of widely used therapeutic agents to treat depression, attention deficit hyperactivity disorder, narcolepsy, obsessive-compulsive disorders, anxiety disorders, nicotine addiction, autism and others. Compounds of this class are a...

A Drug Delivery Composition for Brain Tumor Treatment

A Drug Delivery Composition for Brain Tumor Treatment

Methods for the regulation, stimulation, and inhibition of glial cell-derived neurotrophic factor (GDNF) expression

Lead Inventor: Andreas H. Kottmann, Ph.D. Tech Ventures Reference: IR 2515, 2518 Problem or Unmet Need: Glial cell-derived neurotrophic factor (GDNF) is a target-secreted neuroprotective, neurotrophic, and...

Modulation of Human Stem Cell Migration and Fate In Vitro or After Therapeutic Transplantation for the Treatment of Spinal Cord and CNS Injuries

Researchers at the University of California have been using in vitro experiments and a mouse model to investigate cell based therapies for the treatment of central nervous system ( CNS ) and spinal cord injuries.

Pharmacological Stroke Therapy To Promote Neural Repair And Axonal Sprouting

Injuries to the brain or spinal cord from stroke, trauma or neurodegenerative disease produce a limited reparative response and minimal functional recovery. Current treatment for such injuries is limited to physical rehabilitation and acute intravenous administration of a thrombolytic drug cal...