Small Molecule Read-through Compounds for Treating Genetic Diseases

<p>Approximately 30% of patients with common genetic disorders &#8211; such as Ataxia-telangiectasia (A-T), Duchenne muscular dystrophy (<span class="caps">DMD</span>), and cystic fibrosis (CF) &#8211; carry premature termination codon (<span class="caps">PTC</span>) mutations. Also known as ...

110028: Anti-Biofilm Compound 1 (ABC-1) and Associated Derivative Molecules

Bacteria commonly attach to living and nonliving surfaces in the form of biofilms. In this morphology, the bacteria synthesize a matrix of extracellular polymeric substances (EPS) that provide the biofilm with protection and structural support. The EPS also gives the biofilm resistance to an...

Genistein and Analogues for Treatment of Cystic Fibrosis

<p>Cystic fibrosis is a devastating disease characterized by progressive disability and is one of the most common fatal genetic disorders among Caucasians in <span class="caps">USA</span> and Europe. It is caused by mutations in a channel protein on the cell surface called the cystic fibrosis tra...

Development of Potent Anti-bacterials with a Novel Mode of Action

Drs. Yang and Chen have synthesized several novel chemical compounds which inhibit the expression of the Type III Secretion System (T3SS) virulence genes of the plant pathogens D. dadantii 3937, P. syringae pv tomato DC3000, and Erwinia amylovora as well as the human pathogen Pseudomonas aerugino...

New Therapeutic and Diagnostic Approaches for Liver Fibrosis

<p>Hepatic fibroblasts are activated in response to chronic liver injury and are the source of the fibrous scar in liver fibrosis. Liver fibrosis is known to be reversible. It is thought that reversal of fibrosis is accompanied by senescence and/or apoptosis of the myofibroblasts, which are r...

Transgenic Mice for Testing and Screening Anti-Fibrotic Therapy

Brief description unavailable

Using neuraminidase inhibitors to prevent bacterial infection

Lead Inventor: Alice Prince, M.D. Problem or Unmet Need: Infection by the bacterium Pseudomonas aeruginosa is a major cause of lung disease and death in patients with cystic fibrosis (CF), a genetic disease that causes the accumulation of abnormally ...

A Bioreactor To Quantify Headspace of Volatile Organic Gases From Cells In Culture

The current technology generally relates to systems and devices (e.g., bioreactors) used for collecting and accurately quantifying trace amounts of volatile organic gases (VOCs) obtained from the headspace above cell cultures.

THERAPEUTIC USE OF METHIONINE TO REDUCE THE TOXICITY OF AMINOGLYCOSIDE ANTIBIOTICS

SIU School of Medicine is seeking entities interested in licensing the use of Methionine for the treatment/prevention of toxicity caused by aminoglycoside antibiotics.

Haplotyping using Hybridization Probes

Summary: This invention describes a composite probe design which allows assessment of multiple linked SNPs in cases where variants are separated by a number of nucleotides too great to allow inclusion of the intervening sequence in a single probe.    Probes are designed to be complementary...