Parkinson’s disease

"Parkinson’s disease is the second most common neurodegenerative disease after Alzheimer’s, affecting about one million people in the United States and an estimated four million worldwide. The prevalence of the disease is expected to increase substantially in the next 20 years due to the aging of the population in the U.S., Europe and globally, as well as an increase in the age-related incidence of the disease. The economic burden of Parkinson’s disease is estimated to be $23 billion annually in the U.S. and projected to increase to $5 billion by the year 2040." - National Parkinson Foundation

The Latest Innovations

UCSD TTO 07 FEB 12	Therapeutic Antibody for Psychiatric Disorders <p>Schizophrenia affects 1 percent of the general population and is highly heritable, providing an indication of a genetic basis. Currently, psychiatric disorders are treated with antipsychotics, antidepressants, and mood stabilizers developed by targeting neurotransmitter receptors (e.g. dop...
UND 21 DEC 11	Prevention and Treatment of Neuroinflammation Chronic neurodegenerative disorders are thought to be the result of long-term inflammation. Acute trauma and infection can also trigger inflammatory responses, leading to neuronal death. The present invention utilizes a widely used, FDA-approved compound for prevention and treatment of neuroin...
UND 21 DEC 11	Novel Combination Therapy for Parkinson's Disease and other Age-Related Disorders This invention relates to a therapeutic approach for age-related neurodegenerative disorders, particularly in Parkinson's disease and age-related macular degeneration.
Columbia Tech Ventures 06 DEC 11	Transcriptome Wiring Analysis of Parkinson's Disease Lead Inventors: Asa Abeliovich, M.D., Ph.D. , Herve Rhinn Problem or Unmet Need: Although whole transcriptome gene analysis has identified specific RNA transcripts differentially expressed between brain tissue in patients...
University of Pittsburgh 21 NOV 11	Enhancing Oncolytic Virus Expression to Safely Optimize Efficacy Investigators at the University of Pittsburgh have discovered that the combination of oncolytic virus and a specific chemokine ligand leads to the most effective oncolytic viral delivery, replication and spread inside of a tumor mass
UCLA 21 NOV 11	Aminoacylase 3 (AA3) Inhibitors for the Prevention and Treatment of Alzheimer's and Parkinson's Disease <p>AD is an incurable, neurodegenerative disease afflicting nearly 5 million Americans. PD is the second most common neurodegenerative disorder after Alzheimer’s disease, and affects 2% of people over the age of 60. The dearth of effective treatments and growth of the aging population m...
UWMRF 17 OCT 11	Motion simulator for presenting precision motion inside a magnetic resonance scanner The inventors have developed a computer controlled motion simulator to provide a reference for developing and validating prospective real-time motion correction methods for brain MRI. The objective of the simulator is to provide two controlled degrees of freedom motion of a high resolution spheri...
University of Minnesota 13 OCT 11	MRI Contrast Based on Relaxation along a Fictitious Field (RAFF) The RAFF MRI sequence achieves a unique relaxation time constant along a fictitious field using multiple rotating frames of reference, which provides for lower RF power and therefore less tissue heating. This has the potential to expand diagnostic capabilities of MRI by opening up applications i...
University of Pittsburgh 21 SEP 11	p62-ZZ Small Molecule Inhibitors to Target Multiple Myeloma and Paget’s Disease Investigators at the University of Pittsburgh have developed novel small molecule inhibitors that modulate p62-mediated protein-protein interactions and/or autophagy.
UCSF 20 SEP 11	Improved SPECT Molecular Imaging Technologies Single-photon emission computed topography (<span class="caps">SPECT</span>) imaging generates functional 3D images of internal organs, such as the brain or heart (cardiac imaging).  Radioactive nuclides bound to a targeting ligand are injected into the bloodstream; <span class="caps">SPECT<...
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