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Melanocyte Concentrating Hormone Knockout Mice
Joslin Diabetes Center, Inc.
posted on 03/09/2009
Melanocyte concentrating hormone (MCH) is a cyclic peptide found in fish and mammals. Although involved in regulation of color change in fish, it is localized in the ventral aspect of the Zona Incerta and the lateral hypothalamus in mammals, and was suspected to play a role in complex mammalian behaviors. MCH has been shown to regulate eating behavior in mammals. Specifically, MCH is known to stimulate feeding in rodents, while animals lacking the MCH gene are lean. This molecule and/or its receptor are therefore potentially useful targets for therapeutic intervention to control weight gain or eating behavior. The available technology features transgenic mice, engineered with the MCH gene knocked out. This mouse model is useful in drug screening and development in the field of appetite control.
File Number: JDM-001
Web site: http://www.joslinresearch.org/inventions
Other Information:
Investigator(s)
M.D. Eleftheria Maratos-Flier
Contact
David J. Glass, fax 617-732-2542
This innovation currently is not available for online licensing. Please contact David Glass at Joslin Diabetes Center, Inc. for more information.
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