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Innovation
Bone-Inducing Agent
University of Kansas
posted on 10/03/2005
A bone-inducing agent in extracts of Saos-2 cells that has been used to promote healing of large, surgically-induced bone defects.
Suggested Uses
The development of an agent that promotes bone growth has many potential clinical uses. They include but not limited to:
*Implantation into large bone defects created by surgery for cancer and other diseases to promote bone growth.
*Implantation between broken bone edges to promote the repair of non-union fractures, and to speed the healing of fractures in the elderly, e.g. in hip fractures of osteoporosis.
*Promotion of spinal repair after operations, e.g. after Harrington Rod implacement for scoliosis or after intervertebral disk removal.
*Promotion of bone healing after reparative surgery for large maxiollofacial defects.
*Promotion of bone ingrowth at the interface between in the resection site and an intraosseous implant.
*An untested possibility would be to introduce a bone growth-pomoting agent via the circulation to enhance bone growth in osteoporosis.
*Therapeutics
*Implantation into large bone defects created by surgery for cancer and other diseases to promote bone growth.
*Implantation between broken bone edges to promote the repair of non-union fractures, and to speed the healing of fractures in the elderly, e.g. in hip fractures of osteoporosis.
*Promotion of spinal repair after operations, e.g. after Harrington Rod implacement for scoliosis or after intervertebral disk removal.
*Promotion of bone healing after reparative surgery for large maxiollofacial defects.
*Promotion of bone ingrowth at the interface between in the resection site and an intraosseous implant.
*An untested possibility would be to introduce a bone growth-pomoting agent via the circulation to enhance bone growth in osteoporosis.
*Therapeutics
Innovation Details
Detailed Description
Researchers at the Medical Center have discovered a bone-inducing agent in extracts of Saos-2 cells that has been used to promote healing of large, surgically-induced bone defects.
The Saos-2 cell line originated from an osteosarcoma in an 11 year-old girl, grows a matrix-free monolayer with epithelial-like features, is osteogenically well differentiated in the sense that it strongly expresses alkaline phosphatase, and does not proliferate to form tumors when injected into Nu/Nu mice.
References:
Journal of Musculoskeletal Research, Vol, 3, No 1 (1999) 39-48
Clinical Orthopedics and Related Research (1995) No. 313, 129-134
Curr. Opin. Ther. Patents (1994) 4(1): 17-29
The Saos-2 cell line originated from an osteosarcoma in an 11 year-old girl, grows a matrix-free monolayer with epithelial-like features, is osteogenically well differentiated in the sense that it strongly expresses alkaline phosphatase, and does not proliferate to form tumors when injected into Nu/Nu mice.
References:
Journal of Musculoskeletal Research, Vol, 3, No 1 (1999) 39-48
Clinical Orthopedics and Related Research (1995) No. 313, 129-134
Curr. Opin. Ther. Patents (1994) 4(1): 17-29
File Number: 87KUMC022/047
Other Information: *State of Development* US Patent #6,020,313, #6,322,786 Available for license negotiation.
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