NOVEL MONOMER FOR DENTAL COMPOSITIONS

University of Kansas
posted on 08/11/2009

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Non-Confidential Description: The use of restorative materials in dentistry has been primarily driven by the esthetic features of these materials. Interest in dental materials as an alternative to amalgam has been further promoted by the public’s concern about mercury release from dental amalgam. Despite their extensive use, the short clinical lifetime of materials is a significant limitation. While the clinical lifetime of traditional mercury-containing dental amalgam restorations is generally 10-20 years, the lifetime for methacrylate-based composite restorations is about 8 years in anterior sites and as little as 2-4 years in posterior sites. The primary factor in the premature failure of composite restorations is recurrent caries at the margins of these restorations. Recurrent decay is most often localized gingivally and is linked to the lack of consistent seal at the tooth/material interface. Water in the mouth is a major interfering factor when bonding adhesives and/or composites to the tooth. The water content of the dentin surface varies as a function of depth, the nature of the substrate (i.e. caries-affected or healthy dentin) and the presence of residual rinse water. Effective bonding at the prepared tooth/composite material interface requires dentin adhesives that provide superior properties and rapid polymerization under clinical conditions. The reactivity and the mechanical behavior are influenced by the chemical structures and curing conditions. The present invention involves the development of new methacrylate-based dentin adhesives that show improved esterase-resistance in a moist environment that simulates the mouth. The enhanced esterase-resistance of this newly developed adhesive was accomplished without compromising other physical properties such as degree of conversion (DC) adhesive penetration and thermal and mechanical properties. One of the monomers used in the adhesive formulation was designed to have better biodegradation performance as compared to the control in the moist environment of the mouth.

This new monomer when used as a co-monomer in dental applications can potentially be used in dental composite restorative materials, pit and fissure sealants, and adhesive resin cements for dentistry.

This dental adhesive is more water and esterase resistant