Novel strategies to enhance effectiveness and targeting of drugs in cells by

University of Kansas
posted on 02/25/2006

The invention represents a novel idea for regulating the activity of drugs through rational manipulation of their intracellular localization within a cell. Typically, a drug must be in physical contact with its target molecule contained within a cell for a pharmacological response to occur. Using model small molecule compounds our lab has shown that specific physical/chemical properties can alter the intracellular localization of a small molecule drug like molecules. Ourinvention is to use this information to promote optimal drug to drug target interactions within cells.

Suggested Uses

The application could be used in the design of anticancer agents that specifically targeted cancercells. It could also be used to promote sustained delivery of drugs in selected cells by takingadvantage of lysosomal sequestration.

Innovation Details

Detailed Description

The invention represents a novel idea for regulating the activity of drugs through rationalmanipulation of their intracellular localization within a cell. Typically, a drug must be in physicalcontact with its target molecule contained within a cell for a pharmacological response to occur.Using model small molecule compounds our lab has shown that specific physical/chemicalproperties can alter the intracellular localization of a small molecule drug like molecules. Ourinvention is to use this information to promote optimal drug to drug target interactions within cells.

File Number: KUCR # 2005 FY 28

Other Information: *State of Development* Available for license

IP Protection

License Online

This innovation currently is not available for online licensing. Please contact Jim Baxendale at University of Kansas for more information.

request more info