The XREM-SPAP Reporter Gene and a Validated 96-well Plate Assay for use in the Identification of Novel PXR Ligands

University of Kansas
posted on 08/15/2006

The invention described here is a novel reporter gene (plasmid) that is transactivated by the pregnane X receptor (PXR) transcription factor in the presence of PXR activators.

Suggested Uses

drug-drug interaction, ability to detect a compounds ability to induce drug interactions very early in the drug development process, high throughput process.

Innovation Details

Detailed Description

The invention described here is a novel reporter gene (plasmid) that is transactivated by the pregnane X receptor (PXR) transcription factor in the presence of PXR activators.

File Number: 2005 FY 18

Web site: http://www.people.ku.edu/%7Estauding/

Other Information: *Testing* Complete. Available for license.

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