A Soluble and Stable Synthetic 5-LOX

Louisiana State University
posted on 11/22/2010

This invention is a soluble and stable form of human 5-lipoyxgenase (5-LOX), the enzyme that initiates leukotriene biosynthesis.

Suggested Uses

It is suitable for a number of applications including but not limited to high throughput screening of 5-LOX inhibitors, structural analysis of the enzyme’s active site, designing inhibitors based on the three-dimensional structure of the enzyme’s active site, and synthesis of LTA4.

Advantages

This synthetic 5-LOX enzyme has a longer life than naturally occurring 5-LOX.

Innovation Details

File Number: 1014

Web site: http://uiswcmsweb.prod.lsu.edu/research/intelle...

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