A one-step synthesis method that uses inexpensive reagents and does not require water/oxygen exclusion.
• Pharmaceutical / Health-care: cancer therapeutic
• Pharmaceutical / Health-care: nutraceutical market
• Pharmaceutical / Health-care: macular degeneration/retinopathy
• One-step synthesis method of the marine natural product ageladine A and the use of this method to synthesise a range of analogues.
• The method does not rely on complex, air-sensitive techniques or expensive chemistry and can potentially be carried out on kilogram scales.
In 2005 Associate Professor Peter Karuso identified that the marine natural product ageladine A had never been synthesised. It was first isolated by Fusetani and Nakao et al. (University of Tokyo) in 2003 and shown to have important (antiangiogenic) biological activity that was related to MMP inhibition.
Ageladine A was synthesised at Macquarie in 2005 and was first published in 2006, as a three step synthesis and subsequently as a one-step synthesis. This method devised by Karuso and carried out by Shengule was patented in 2008. Subsequently approximately 20 analogues have been synthesised.