NR-6-R Cells for the Study of FGFs

University of Nebraska System: University of Nebraska Medical Center
posted on 08/24/2010

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Fibroblast Growth Factors (FGFs) and fibroblast growth factor receptors together form a highly conserved signaling system that is used in both developmental and physiological processes of the adult. The 18 known FGFs are involved in the development and homeostasis of virtually every human tissue. Given its ubiquity, establishing FGF activity is a critical step in understanding a wide variety of biological processes. Scientists at the University of Nebraska Medical Center have substantial expertise in assaying FGFs. Specifically, the isolation of NR-6-R cells and their use as a highly sensitive bioassay for FGFs was first reported by Dr. Angie Rizzino at UNMC within the Eppley Institute for Research in Cancer and Allied Diseases. NR-6-R cells are a versatile and sensitive tool for determining FGF activity and have been employed in a variety of assays. UNeMed is currently offering licensing opportunities for the NR-6-R cells produced in Dr. Rizzino’s laboratory. The cells can be employed in a wide variety of assays, such as soft agar assays and proliferation assays, to identify and measure FGF activity.