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Biaryl Amino Acids as Modulators of Nuclear Receptor Coregulatory Protein Binding
Northeastern University
posted on 04/16/2009
The invention describes novel synthesized compounds that modulate hormone receptors. Use of these compounds allows for a more specific and targeted approach to the modulation process (i.e. “personalized medicine”).
Suggested Uses
• Wide range of endocrine disorders (i.e. diabetes, obesity)
• Treatment of inflammation
• Hormone replacement therapy
• Treatment of cancer (i.e. breast, prostate, etc.)
Advantages
• Increased selectivity
• Higher specificity and targeting
• More stable than peptides
• Fewer side effects
• Orally active
• Many variations may be made to match a
particular disorder (“personalized medicine”)
Detailed Description
This invention describes novel synthesized compounds that modulate hormone receptors. Use of these compounds allows for a more specific and targeted approach to the modulation process. The ability to block a very small subset of responses within the large field results in a much more focused therapy with fewer side effects. Users will be able to make many different variations in order to match a particular disorder. The applications for this technology are broad and wide-ranging.
Data from this research has been tested in vitro with excellent results. This invention will allow for generation of compounds in a broad variety of pharmacology. Previous approaches for modulating hormone receptor function have broad side effects, and have difficulty controlling selectivity. In comparison, this approach has much better selectivity and fewer side effects.
File Number: INV-0844/US
Other Information:
Investigator(s)
Robert Hanson
Contact
Susan Riley Keyes, s.keyes@neu.edu
| Patent Number(s): | PCT/US09/37986 |
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This innovation currently is not available for online licensing. Please contact Susan Keyes at Northeastern University for more information.
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