A physiological assay for purposes of psychotic disorders like schizophrenia where patients experience confusion, dellusion, hallucination, and general disorganization of thought.
Advantages
There is no existing physiological model for psychosis and thus no physiological assays for antipsychotic efficacy. The assay can be performed in one afternoon. The assay is reliable, relatively easy to induce and record. It is specific and one knows where to look and what brain changes are important for the antipsychotic action to counter.
Detailed Description
A large percentage of the international population is affected with some sort of psychotic disorder if left undiagnosed and untreated could result in injury to the person with the disorder and/or to people associated and/or close to the person with the disorder. Diagnosis of a psychological disorder can often take time to properly diagnose with only a handful of approved drugs available to treat such disorders once they are diagnosed. Also, conventional methods of determining the anti-psychotic properties of a candidate agent are often times consuming and costly. Very few new candidates that are totally different from existing drugs ever make it to the discovery stage because of a lack of money when this stage is reached. In 2005 a NIH-funded study found treatments with contemporary antipsychotics were no more effective than with drugs that were introduced up to 40 years ago. In the brain, cognitive representations of external stimuli and thought (