Evaluation and Increased Vaccine Efficacy through Expression of Alpha-1 Integrin on T Cells

University of Rochester
posted on 07/01/2009

Suggested Uses

Disclosed are methods for evaluating efficacy of an immune response by assessing alpha-1 integrin, screening for, and manufacturing those therapeutic agents. Described herein the presence of VLA-1+ (positive) T cells indicates an effective immune response. Also disclosed are methods of screening for antigens that induce the production of VLA-1+ (positive) T cells, methods of isolating the antigens, and methods using the antigens identified in the screening methods to treat a subject with a disease.

Advantages

This technology will allow for the identification of optimum adjuvants to use with a variety of antigens, the identification of what components of a vaccine program are likely to achieve a protective immune response, and the quick evaluation of the effectiveness of a vaccine strategy

Detailed Description

Disclosed are methods for evaluating efficacy of an immune response by assessing alpha-1 integrin, screening for, and manufacturing those therapeutic agents. Described herein the presence of VLA-1+ (positive) T cells indicates an effective immune response. Also disclosed are methods of screening for antigens that induce the production of VLA-1+ (positive) T cells, methods of isolating the antigens, and methods using the antigens identified in the screening methods to treat a subject with a disease.

This technology will allow for the identification of optimum adjuvants to use with a variety of antigens, the identification of what components of a vaccine program are likely to achieve a protective immune response, and the quick evaluation of the effectiveness of a vaccine strategy

File Number: 6-1293

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