Innovation

Control of Immunodominance in T-Cell Immune Responses to Antigen by Manipulation of the Kinetic Stability of Peptide: MHC Complexes

University of Rochester
posted on 07/01/2009

Control of Immunodominance in T-Cell Immune Responses to Antigen by Manipulation of the Kinetic Stability of Peptide: MHC Complexes

Suggested Uses

This invention uncovered a principle that can be used in vaccine design for those pathogens that are subject to rapid genetic changes, such as influenza or HIV. This invention provides a method to design vaccines focusing on the immune response against regions of the pathogens that do not readily mutate.

Advantages

This invention presents a superior method to promote immunity by manipulating immunodominance in immune responses other than manipulating other aspects of antigens or pathogens. Researchers have identified a key parameter that controls the potency of a peptide in eliciting a T cell immune response. More over, this parameter is experimentally more accessible and easily controllable.


Innovation Details
 

Detailed Description

This invention uncovered a principle that can be used in vaccine design for those pathogens that are subject to rapid genetic changes, such as influenza or HIV. This invention provides a method to design vaccines focusing on the immune response against regions of the pathogens that do not readily mutate.

This invention presents a superior method to promote immunity by manipulating immunodominance in immune responses other than manipulating other aspects of antigens or pathogens. Researchers have identified a key parameter that controls the potency of a peptide in eliciting a T cell immune response. More over, this parameter is experimentally more accessible and easily controllable.

File Number: 6-1430 

Other Information:

  • Refer to: Case # 6-1430
  • Lead Innovator: Andrea Sant
  • Case Manager: Harl Tolbert
  • Harl_Tolbert@urmc.rochester.edu


IP Protection


License Online

This innovation currently is not available for online licensing. Please contact Harl Tolbert at University of Rochester for more information.

Request more info via email request more info
People

Case Manager:

Harl Tolbert Harl Tolbert

Innovations (25)


Download Technology Brief (PDF)


Followed By

Follow this innovation



No one is following this innovation.

Organization
Communities
Profile
Related Tags

Find more innovations


February 11, 2009

7,783 members 17,070 innovations 152 organizations

Browse

Scott Steele, coordinator of the CTSA-IP initiative and director of research alliances at the University of Rochester

"With more than 3,700 innovations from CTSA member institutions already on the iBridge Network, we're garnering worldwide exposure for the breakthroughs our researchers are accomplishing while moving toward our goal of increasing human health through clinical and translational research."  read more...