Control of Immunodominance in T-Cell Immune Responses to Antigen by Manipulation of the Kinetic Stability of Peptide: MHC Complexes

University of Rochester
posted on 07/01/2009

Suggested Uses

This invention uncovered a principle that can be used in vaccine design for those pathogens that are subject to rapid genetic changes, such as influenza or HIV. This invention provides a method to design vaccines focusing on the immune response against regions of the pathogens that do not readily mutate.

Advantages

This invention presents a superior method to promote immunity by manipulating immunodominance in immune responses other than manipulating other aspects of antigens or pathogens. Researchers have identified a key parameter that controls the potency of a peptide in eliciting a T cell immune response. More over, this parameter is experimentally more accessible and easily controllable.

Detailed Description

This invention uncovered a principle that can be used in vaccine design for those pathogens that are subject to rapid genetic changes, such as influenza or HIV. This invention provides a method to design vaccines focusing on the immune response against regions of the pathogens that do not readily mutate.

This invention presents a superior method to promote immunity by manipulating immunodominance in immune responses other than manipulating other aspects of antigens or pathogens. Researchers have identified a key parameter that controls the potency of a peptide in eliciting a T cell immune response. More over, this parameter is experimentally more accessible and easily controllable.

File Number: 6-1430

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