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Novel Conditionally Replicating Adenivirus Vector and Improved Method for Use Thereof
University of Rochester
posted on 07/01/2009
Novel Conditionally Replicating Adenivirus Vector and Improved Method for Use Thereof
Suggested Uses
Oncolytic conditionally replicating adenoviruses (CRAD) that replicate and induce lysis selectively in tumor cells have been developed as a novel genetic approach for the treatment of cancer.
Advantages
Although this approach has demonstrated promising results in phase I and II clinical trials, these CRADs have limitations which restrict their use to specific types of cancer or cancerous cell types. This technology describes a novel approach to the generation of oncolytic CRAD that will overcome these limitations.
Detailed Description
Oncolytic conditionally replicating adenoviruses (CRAD) that replicate and induce lysis selectively in tumor cells have been developed as a novel genetic approach for the treatment of cancer.
Although this approach has demonstrated promising results in phase I and II clinical trials, these CRADs have limitations which restrict their use to specific types of cancer or cancerous cell types. This technology describes a novel approach to the generation of oncolytic CRAD that will overcome these limitations.
File Number: 6-1455
Other Information:
- Refer to: Case # 6-1455
- Lead Innovator: Dr. Baek Kim
- Case Manager: Harl Tolbert
- Harl_Tolbert@urmc.rochester.edu
This innovation currently is not available for online licensing. Please contact Harl Tolbert at University of Rochester for more information.
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