Novel Conditionally Replicating Adenivirus Vector and Improved Method for Use Thereof

University of Rochester
posted on 07/01/2009

Suggested Uses

Oncolytic conditionally replicating adenoviruses (CRAD) that replicate and induce lysis selectively in tumor cells have been developed as a novel genetic approach for the treatment of cancer.

Advantages

Although this approach has demonstrated promising results in phase I and II clinical trials, these CRADs have limitations which restrict their use to specific types of cancer or cancerous cell types. This technology describes a novel approach to the generation of oncolytic CRAD that will overcome these limitations.

Detailed Description

Oncolytic conditionally replicating adenoviruses (CRAD) that replicate and induce lysis selectively in tumor cells have been developed as a novel genetic approach for the treatment of cancer.

Although this approach has demonstrated promising results in phase I and II clinical trials, these CRADs have limitations which restrict their use to specific types of cancer or cancerous cell types. This technology describes a novel approach to the generation of oncolytic CRAD that will overcome these limitations.

File Number: 6-1455

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