A Novel Method for the Production of Nanoscale Membrane Particles

The Rockefeller University
posted on 01/26/2010

There are currently considerable research efforts on membrane-associated proteins in both academic and commercial settings. Academic researchers are intrigued by questions of ligand activation, assembly, multimerization, etc. Many companies view these proteins as potential drug targets as they can be accessed from outside of the cell. At the same time, these membrane proteins can be very difficult to study due to in-vitro solubility and stability issues. Apolipoproteins are called

Suggested Uses

NABBS are ideal platforms to study transmembrane receptors, viral membrane protein or ion channels by structural studies (Xray crystallography, EM imaging, NMR), and conventional assays.

Advantages

The NABBs are easy to prepare in a scalable manner, including on a large scale (grams).

Innovation Details

File Number: RU 870

Web site: http://rockefeller.edu/techtransfer/RU870.pdf

Other Information: Principal Investigator: Banerjee, et al. 2008. J. Mol. Biol. DOI: 10.1016/j.jmb.2008.01.066

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This innovation currently is not available for online licensing. Please contact Nidhi Sabharwal at The Rockefeller University for more information.

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