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Intelligent Antibacterial Therapeutic
Schepens Eye Research Institute
posted on 02/04/2010
Age-related macular degeneration (AMD) is caused by the deterioration of the central portion of the retina, the inside back layer of the eye. The diagnosis of AMD depends on dilated eye examination by an ophthalmologist: typically, the early visible signs of AMD include presence of yellow subretinal deposits called drusen, pigment migration of the retinal pigment epithelium and small areas of retinal atrophy. Unfortunately, it takes years for these clinical signs to develop, when the disease is well into its course.In an effort to develop an early diagnosis of AMD, Dr. Lashkari has studied the role of cytokines in the pathogenesis of age-related macular degeneration and found that serum concentrations of IP-10 and Eotaxin are significantly increased in AMD patients.AMD is an incurable eye disease that is the leading cause of blindness for those aged 55 and older in the United States, affecting more than 10 million Americans. The early detection of AMD biomarkers in serum would identify individuals who are at high risk for development of AMD to challenge the course of the disease through life-style changes or therapeutics.
File Number: SERI-234
Other Information:
Investigator(s)
M.D. Kameran Lashkari
Contact
Mary Chatterton, Director of Corporate Alliances. mary.chatterton@schepens.harvard.edu.
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