Innovation

Preventing Diabetic Cardiovascular Disease

Schepens Eye Research Institute
posted on 03/04/2009

Atherosclerosis-related events such as myocardial infraction and stroke are two- to four- fold more prevalent in adults with diabetes as compared to those without diabetes. The invention focuses on the protein profilin-1 (pfn) as a mediator in diabetic vascular injury. Pfn levels are increased in the aortic endothelium and within atherosclerotic plaques and pfn knockout mice are protected against plaques onset. Circulating levels of profilin-1 could be used to predict the development of cardiovascular events and inhibition of profilin-1 accumulation would prevent the progression of atherosclerotic diseases.Diabetic vascular complications account for the vast majority of mortality occurring in diabetic patients. For at least 20 years, diabetes rates in North America have been increasing substantially affecting more than 20 million people in the United States alone. There is currently no biomarker for the diagnostic of atherosclerosis vascular diseases.


Innovation Details
 

File Number: SERI-147 

Other Information:

Investigator(s)
Ph.D Andrius Kazlauskas

Contact
Mary Chatterton, Director of Corporate Alliances. mary.chatterton@schepens.harvard.edu.


IP Protection


License Online

This innovation currently is not available for online licensing. Please contact the case manager at Schepens Eye Research Institute for more information.

Request more info via email request more info
People

No people are currently associated with this innovation.


Download Technology Brief (PDF)


Followed By

Follow this innovation



No one is following this innovation.

Organization
Communities
Profile
Related Tags

Find more innovations


February 11, 2009

12,586 members 18,787 innovations 176 organizations

Browse

Alan Thomas, Director, UChicagoTech

"The iBridge Network has opened up new avenues for innovations at UChicagoTech. Relationships between researchers from other universities or industry can be built and strengthened, while investors can find new technologies to advance. "  read more...