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An Assay for Screening/Ranking Antioxidants Based on Their Effects on Membrane Sterol Lateral Organization
Temple University
posted on 03/05/2009
A method of screening an antioxidant for potency and/or toxicity in vitro, the method includes contacting the antioxidant with a model system comprising a sterol superlattice formation capable of generating a detectible signal, wherein the detectible signal changes in a parameter representative of an integrity of the sterol superlattice formation; and detecting and/or measuring disruption of the sterol superlattice formation, wherein the disruption is caused by oxidation of sterol upon contacting sterol with a prooxidant and the antioxidant and thereby screening the antioxidant for potency and/or toxicity.
File Number: 578PC
Web site: http://www.temple.edu/ott
| Patent Number(s): | WO2009/015307 |
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