Follow this innovation
[ via 
] [?]
Process for Synthesis of Silane Dipeptide Analogs
Temple University
posted on 08/05/2011
The present invention relates to the unexpected discovery that a substituted 1,2-oxasilolane may be efficiently converted to the dilithium salt of a substituted 3-hydroxypropylsilanol using lithium metal, which reductively cleaves the Si-O bond in high yields. The substituted 1,2-oxasilolane starting material is easy to prepare and purify and does not present the same handling problems as chlorosilanes, which have been previously utilized in the synthesis of silyl lithium compounds. The dilithium salt of the 3-hydroxypropylsilanol may be reacted with various nucleophiles. The chemistry disclosed herein may be used to synthesize a silanediol-based dipeptide analog in high yield and in fewer synthetic steps than previously reported.
Suggested Uses
• Silane dipeptide analogs are useful as protease inhibitors. These inhibitors have been used for the treatment of various cancers, notably multiple myeloma.
File Number: 689SS
| Patent Number(s): | 61/346516 |
|---|
This innovation currently is not available for online licensing. Please contact Stephen Nappi at Temple University for more information.
request more info
ProfileFind more innovations
