Use of miRNAs to selectively modulate TGF-ß/BMP signaling to treat TGF-ß/BMP mediated disorders

Tufts Medical Center
posted on 01/07/2009

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Tufts Medical Center Categories:
diseases:cancer
diseases:cardiovascular
diseases:endocrine
therapeutic:antisense
therapeutic:cell signalling

Additional Keywords:
miRNA therapeutics

Invention Summary

Available from Tufts Medical Center

Patent application claims miRNA compositions and methods useful for modulating the TGF-ß/BMP signaling pathway. Tufts Medical Center scientists discovered that miRNAs are regulated by and play a role in a TGF-ß/BMP signaling pathway and that SMAD associates with a component of the Drosha microprocessor complex, generating responses involved in the TGF-ß/BMP signaling pathway. This invention provide a mechanism to use miRNAs to selectively modulate TGF-ß/BMP signaling to treat TGF-ß/BMP mediated disorders. See also: Davis BN, Hilyard AC, Lagna G, Hata A., SMAD proteins control DROSHA-mediated microRNA maturation., Nature. 2008 Jun 11.