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Chiral Separation Medium
University of California System: University of California, Berkeley
posted on 05/28/2009
An electrochromatographic device is provided for conducting enantioselective separation of enantiomers. The device is comprised of a conduit containing a monolithic enantioselective separation medium, and may be, for example, a capillary tube or a microchannel in a substrate. The enantioselective separation medium is prepared by copolymerization of (a1) an ionizable chiral monomer or (a2) a chiral monomer and an ionizable comonomer, along with (b) a crosslinking comonomer and © a polymerization initiator, in (d) a porogenic solvent. Following ionization, the enantioselective separation medium serves as a charge carrier as well as a chiral separation medium, and further acts as an electroosmotic pump to facilitate the flow of a fluid. The invention also provides methods for preparing the enantioselective separation medium and electrochromatographic devices fabricated therewith.
Suggested Uses
This invention relates generally to the field of electrochromatographic separation, and more particularly relates to a novel enantioselective separation medium comprised of a monolithic, chiral, ionizable copolymer.
Advantages
The invention also provides methods for preparing the enantioselective separation medium and electrochromatographic devices fabricated therewith.
File Number: 16987
| Patent Number(s): | 6616825 |
|---|---|
| Copyright: | ©2009-2010, The Regents of the University of California |
This innovation currently is not available for online licensing. Please contact Javed Afzal at University of California System: University of California, Berkeley for more information.
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