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Rapid Inexpensive Fluoroimmunoassay Diagnostic Chip Fabricated from Polyolefin Coated with a Thin Film
University of California System: University of California, Irvine
posted on 01/30/2012
Immunoassays have a tremendous range of uses in the diagnosis of diseases, pharmaceutical drug development studies, and therapeutic drug monitoring.They are highly popular due to their high specificity and sensitivity for a variety of analytes in biological samples.However, immunoassays can be labor intensive, time consuming, and require expensive reagents.An immunoassay method that is rapid, inexpensive, and highly effective would be practical and may have widespread use. Researchers at the University of California, Irvine have developed a fluoroimmunoassay chip that can be used for improving the detection of low concentration (approx. 1 nM) biological agents.The method is rapid, inexpensive, and provides a fluorescence enhancement that is approximately 30-fold greater than glass.In addition, this method does not use the principle of metal enhanced fluorescence to enhance the signal, so the fluorophore is not distance dependent in order to achieve enhancements.
Suggested Uses
The invention may be integrated into a microfluidic device and be used as an immunoassay to detect for infectious diseases.
File Number: 22233
Disease: Infectious Diseases
| Copyright: | ©2012, The Regents of the University of California |
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