Genes Dysregulated in Autism as Potential Biomarkers and Therapeutic Targets
University of California System: University of California, Los Angeles - UCLA
posted on 05/02/2012
Brief description unavailable
-Can be used as genetic biomarkers for the accurate and early diagnosis of ASD in
-Describes the dysregulated molecular pathways that may include candidates for
preventive approaches or treatment therapeutics for ASD patients.
-Some of the gene changes are also seen in peripheral blood lymphocytes,
indicating that they may serve as biomarkers for ASD diagnosis.
Researchers at UCLA have characterized the genome-wide expression profiles of
postmortem brain tissue from several brain regions in ASD patients and controls. They
identified numerous genes showing consistent changes in expression level and employed
a network-based approach to identify groups of functionally-related genes that are
aberrantly expressed in the ASD brain. These analyses highlight genes that are
dysregulated in ASD in the disease-relevant tissue, and define a set of co-expressed genes
that may serve as therapeutic candidates or potential biomarkers for the disease. Some of
the identified genes also change in peripheral blood lymphocytes, suggesting that these
genes may serve as diagnostic biomarkers in peripheral tissue samples. The molecular
entities identified herein can be utilized as a genetic diagnostic test for ASD, or exploited
for the discovery and development of ASD therapeutics.
File Number: 22469
Disease: Central Nervous System
children, and its prevalence continues to increase. The lack of effective means of genetic
diagnosis, prevention, and treatment emphasizes the importance of identifying
biomarkers and molecular pathways implicated in ASD. Most studies of gene expression
in ASD have profiled only peripheral tissues, which show expression patterns that largely
differ from that of brain tissue. Gene expression changes in the ASD brain may serve as
relevant biomarkers for diagnosis, or as therapeutic targets for disease treatment.
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