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Affinity Hydrogels for Controlled Protein Release
University of Connecticut
posted on 08/08/2011
Current methods for the preparation of protein release systems are often complicated and risk structural disruption or side chain modification, which can result in a significant loss of protein bioactivity or an undesired immune response. Because hydrogels can be prepared under physiological conditions in a variety of formats such as particles, films, coatings, and slabs, they are more appealing than organic polymer-based delivery systems, but they suffer from rapid release kinetics due to their high permeability.
Detailed Description
Dr. Wang’s affinity hydrogel technology utilizes nucleic acid aptamers to entrap one or more proteins within the hydrogel matrix. Unlike other polymeric delivery systems, protein release from the affinity hydrogel is not dependent upon degradation of the hydrogel. Instead, the release kinetics can be tuned by modulating the binding affinity of the aptamers or, if desired, a triggered release of protein is possible. The preparation of protein release formulations is very simple and reproducible and no toxic molecules or harsh conditions are involved during hydrogel preparation, protein loading and protein release.
File Number: 09-096
Other Information:
PCT patent application filed.
This innovation currently is not available for online licensing. Please contact Gregory Gallo at University of Connecticut for more information.
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