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Ncrna As Epigenetic Switch
University of California System: University of California, Riverside
posted on 09/21/2010
Long, intergenic non-coding RNAs ( lincRNAs ) have been associated with various epigenetic phenomena such as imprinting, gene dosage, composition and silencing. Using a combination of molecular, biochemical and cell assays to dissect the role of lincRNAs in epigenetic activation of gene expression, UCR’s Professor Frank Sauer and his team have identified a novel lincRNA which acts as an epigenetic “Switch ”. 
Image Illustrating the Distribution of non-Coding RNA in the Cell Nucleus. The RNAi -mediated destruction of this lincRNA attenuates the proliferation of undifferentiated and differentiating human teratocarcinoma cells, identifying it as a protagonist of cell proliferation. These observations provide insights into the role of lincRNAs in the molecular mechanisms underlying the dynamics of epigenetic gene expression and shed light onto the molecular networks controlling cell proliferation in development and disease. The mission of UCR’s Office of Technology Commercialization (OTC) is to insure that research results are made available for public use and benefit. For this purpose, OTC is currently marketing this technology to industry.
| Copyright: | ©2010, The Regents of the University of California |
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This innovation currently is not available for online licensing. Please contact Michael Arciero at University of California System: University of California, Riverside for more information.
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