Innovation

A Novel Technique for Fabricating Biomolecular Nano-Arrays Enabling High-DNA Amplification and Sequencing

University of California System: University of California, San Diego
posted on 07/01/2009

Brief description unavailable

Suggested Uses

This technology may be applied to high-throughput genome sequencing, protein array analysis, and bio-sensors.


Innovation Details
 

Detailed Description

This invention provides a new approach for fabricating high-density nano-arrays for bio-molecules. Researchers used glass slides derivatized with functional groups, then coated them with a thin layer of photo-resist. Conventional photolithography is then used to create high-density wells of sub-micron dimension into which nano-particles conjugated to a single DNA clone are allowed to self-assemble. The small size of the wells prevents more than one molecule from attaching in any given well. The nano-particles remain fixed in their wells through biotin-avidin with the remaining non-specifically bound nano-particles being washed away with the removal of the remaining photo-resist. This leaves a very clean array for high throughput sequencing.

File Number: 19180 

Other Information:

This invention has a patent pending.


IP Protection

Patent Number(s): 2010/0120630
Copyright: ©2009-2014, The Regents of the University of California

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This innovation currently is not available for online licensing. Please contact University of California, San Diego Technology Transfer Office at University of California System: University of California, San Diego for more information.

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February 11, 2009

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