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A Novel Technique for Fabricating Biomolecular Nano-Arrays Enabling High-DNA Amplification and Sequencing

University of California System: University of California, San Diego
posted on 07/01/2009

Brief description unavailable

Suggested Uses

This technology may be applied to high-throughput genome sequencing, protein array analysis, and bio-sensors.

Innovation Details

Detailed Description

This invention provides a new approach for fabricating high-density nano-arrays for bio-molecules. Researchers used glass slides derivatized with functional groups, then coated them with a thin layer of photo-resist. Conventional photolithography is then used to create high-density wells of sub-micron dimension into which nano-particles conjugated to a single DNA clone are allowed to self-assemble. The small size of the wells prevents more than one molecule from attaching in any given well. The nano-particles remain fixed in their wells through biotin-avidin with the remaining non-specifically bound nano-particles being washed away with the removal of the remaining photo-resist. This leaves a very clean array for high throughput sequencing.

File Number: 19180 

IP Protection

Patent Number(s): 9063133
Copyright: ©2009-2015, The Regents of the University of California

License Online

This innovation currently is not available for online licensing. Please contact University of California, San Diego Technology Transfer Office at University of California System: University of California, San Diego for more information.

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February 11, 2009

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