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Compositions and Methods for Tympanic Membrane Transmigration
University of California System: University of California, San Diego Technology Transfer Office
posted on 01/19/2012
Otitis media is one of the most common diseases of childhood, resulting in more physician visits and surgeries than any other pediatric disorder. Persistent or recurrent otitis media can damage the middle or inner ear and cause permanent hearing loss. There exists a need to identify targets for potential new therapies in this disease.
Detailed Description
Medical researchers at UC San Diego have established that it is possible to translocate particles across the tympanic membrane and have the potential for drug delivery to the inner ear. Historically the eardrum was viewed as impermeable to particles. This invention identifies specific compositions capable of transmigrating particles across the eardrum, as well a description of the process to identify compositions capable of translocating particles across biological membranes.
This technology has potential for treating numerous ear disorders (e.g. acute otitis media, recurrent ototos media, chronic otitis media, purlulent otitis media, otitis media with effusion, cholesteatoma, tympanosclerosis, otosclerosis, tinnitus, vertigo, Meniere’s disease, and various forms of sensorineural hearing loss).
File Number: 22225
| Copyright: | ©2012, The Regents of the University of California |
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This innovation currently is not available for online licensing. Please contact University of California, San Diego Technology Transfer Office at University of California System: University of California, San Diego Technology Transfer Office for more information.
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