Innovation

Sustained release, temperature sensitive, biodegradable hydrogel

University Health Network - Technology Development and Commercialization
posted on 11/23/2010

The technology is a novel thermoplastic, non-toxic, biodegradeable multi-block hydrogel copolymer used in cellular, protein and molecule delivery, having both hydrophobic and hydrophilic blocks.

Suggested Uses

wound healing, local drug delivery, tissue regeneration after heart attack to improve heart function, cellular therapies, cosmetics, etc.

Advantages

The UHN researchers developed a novel, temperature sensitive and biodegradable hydrogel. The unique advantages of the biomaterial are following:

  • Temperature sensitive: The injectable biomaterial is in liquid form at room temperature, in which biological molecules can be evenly mixed and solution is injectable. The biomaterial solution forms gel at 37°C (body temperature), which sustains a release profile of biological molecule through diffusion and gel degradation processes in tissue and maintain higher concentration locally.
  • Biological compatible: The bio-polymers are used clinically. The biomaterial is biodegradable and degraded molecules are non-toxic materials.
  • Biological molecules in the hydrogel can be released by slow diffusion as well as during biodegradation of the gel.
  • Biological molecules can also be conjugated to the hydrogel which provided a scaffold for sustained release of biological molecules.
  • Long Storage Life: several samples were kept at 4 ˚C for two years. When it was injected into animal models, the samples still formed hydrogel.

    • Innovation Details
     

    Detailed Description

    The temperature sensitive hydrogel can be used alone as biomaterial to repair damaged tissue. The hydrogel can also be used as carrier to locally deliver drugs, cytokines, growth factors, etc. for regional therapy, specifically the VEGF, SCF and SDF in our research. The hydrogel can also be used to deliver stem cells for tissue regeneration. Most importantly, the hydrogel can mix stem cells and growth factors to yield synergistic effect.

    This technique can be used wound healing, local drug delivery for cancer therapy (hydrogel without VEGF conjugated), tissue regeneration after heart attack to improve heart function.

    File Number: 1-0031 


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    License Online

    This innovation currently is not available for online licensing. Please contact Yuan Lew at University Health Network - Technology Development and Commercialization for more information.

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    Case Manager:

    Yuan Lew Yuan Lew

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