DMP1 Mouse Model for Osteocyte Research

University of Missouri System: University of Missouri-Kansas City
posted on 03/03/2010

A DMP1 mouse model used for gene targeting in bone function and structure.

Suggested Uses

This mouse model is very useful in any study focusing on bone growth, or diseases of the bone.

Advantages

Dmp1-lacZ is a good marker which is expressed in osteocytes, and useful in the research of diseases such as osteoporosis and osteosclerosis.

Innovation Details

Detailed Description

Background:

Dentin Matrix Protein-1 (Dmp-1) is critical for normal bone function and structure. Dmp1 is essential for normal mineralization of the skeleton and to maintain normal phosphate metabolism. Humans with mutations in this gene/protein show features of bone abnormalities.

Need:

A mouse model with similar features of human gene/protein mutations is needed to improve osteocyte research.

Invention Description:

This invention identifies the portion of the DMP1 promoter that is responsible for its activity in osteocytes. 10 kb-Dmp1-Cre mice have been generated and tested by crossing to lacZ reporter mice. The results show this DMP1 promoter is highly specific in osteocytes.

File Number: 07UMK106

Web site: http://www.umkc.edu/ors/tt/

Disease: Musculoskeletal Disorders

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This innovation currently is not available for online licensing. Please contact James Brazeal at University of Missouri System: University of Missouri-Kansas City for more information.

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