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DNA and deduced amino acid sequence of the heme receptor of Haemophilus ducreyi.
University of North Carolina at Chapel Hill
posted on 08/14/2006
In Haemophilus ducreyi (H. ducreyi), DsrA plays a role in the pathogenesis of chancroid and as a virulence factor. Serum-susceptible DsrA mutant strains may make excellent vaccine candidates.
Detailed Description
Haemophilus ducreyi is the etiologic agent of chancroid, a genital ulcer disease transmitted by sexual contact and a risk factor for the heterosexual transmission of human immunodeficiency virus (HIV) in Africa. In H. ducreyi, serum resistance is correlated with virulance and DsrA expression. Naturally occuring or recombinant DsrA mutants are serum susceptible and may make excellent vaccine candidates.
File Number: 99-0005
Other Information:
State of Development
pre-clinical
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