Fixed-Dried Red Blood Cells
University of North Carolina at Chapel Hill
posted on 08/14/2006
Methods for the stabilization of cellular structures with chemicalcross-linkers and lyophilizations in the preparation of red blood cells for long-term storage.
Detailed Description
Red blood cells can be stored for up to 42 days at reduced temperatures. In order to minimize the logistical complexities of blood banking fresh and cryopreserved RBCs, these methods have been developed for preparing lyophilized RBCs with a prolonged shelf-life for infusion after simple rehydration. This process allows for the retention of cell membrane elasticity and partial deformability, oxygen binding with native affinity, and presents minimal thrombogenicity to platelets.
File Number: 00-0086
Other Information:
State of Development
pre-clinical
This innovation currently is not available for online licensing. Please contact Scott Forrest at University of North Carolina at Chapel Hill for more information.
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