This method uses combinatorial peptide libraries to identify peptides that bind to DNA in a sequence-specific manner. This can be used to identify peptides that bind to any target DNA sequence and thereby modify gene expression, especially peptides that target promoter sequences, 5’ regulatory sequences, 3’ regulatory sequences, or exon and intron regulatory sequences. Such peptides can potentially block initiation of transcription if targeted to 5’ regulatory regions of genes, or block transcriptional processing if targeted to exon or intron sequences.

File Number: 96-0063