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Methods and Compositions for Infectious cDNA of SARS Coronavirus
University of North Carolina at Chapel Hill
posted on 08/14/2006
Genetic engineering approach to reducing recombination events in RNA viruses and providing for more stable attenuated vaccines.
Detailed Description
Live virus vaccines provide significant protection against many detrimental human and animal diseases, but reversion to virulence by mutation and recombination with wild type virus has reduced appeal. Using severe acute respiratory syndrome coronavirus (SARS) as a model, researchers have introduced transcription regulatory sequences into the viral genome that are lethal in RNA recombinant viruses. Live virus platforms that encode new regulatory circuits provide a means for enhancing vaccine safety and stabilizing attenuating mutations.
File Number: 03-0082
Other Information:
State of Development
pre-clinical
This innovation currently is not available for online licensing. Please contact Kelly Sivertson at University of North Carolina at Chapel Hill for more information.
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