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Modulation of Epidermal Growth Factor Heterodimer Activity
University of North Carolina at Chapel Hill
posted on 08/11/2006
A method of screening for compounds which bind to and modulate the activity and/or formation of pathological EGFR-ERBB heterodimers without inhibiting normal receptor function.
Detailed Description
The formation of EGFR homodimers and ERBB family heterodimers are critical to normal receptor function. However, EGFR-ERBB heterodimers are associated with cell transformation and tumor growth. Current inhibitors of ERBB or EGF target these pathways non-specifically, leading to undersirable side effects. This method allows for targeting screening of compounds that inhibit only EGFR-ERBB heterodimers.
File Number: 04-0056
Other Information:
Testing
pre-clinical
This innovation currently is not available for online licensing. Please contact Scott Forrest at University of North Carolina at Chapel Hill for more information.
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