Use of Lactoferrin N-terminus to Neutralize Heparin
University of North Carolina at Chapel Hill
posted on 08/14/2006
Lactoferrin can be used to regulate blood coagulation by inhibiting and/or regulating anticoagulant activity, including the neutralization of heparin.
Detailed Description
A patient receiving cardiopulmonary bypass, cardiac catheterization, and hemodialysis is administered heparin when undergoing such surgical procedures to “thin” the patient’s blood. A second compound is typically then administered following completion of the surgical procedure to neutralize the heparin. TheN-terminus of lactoferrin, an iron-binding protein contains heparin-binding consensus sequences. Lactoferrin or polpeptides derived from the N-terminus can be used to regulate blood coagulation by inhibiting and/or regulating anticoagulant activity, including the neutralization of heparin.
File Number: 95-0038
Other Information:
State of Development
pre-clinical
This innovation currently is not available for online licensing. Please contact Earl Smith at University of North Carolina at Chapel Hill for more information.
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