Innovation

Kinase Inhibitors as Potential Therapeutics in Neurological Disorders

University of Missouri System: Missouri University of Science and Technology
posted on 02/07/2011

A series of novel fluorinated kinase inhibitors that can be used in cell cycle suppression in vulnerable neurons

Suggested Uses

• Developing drug candidates

Advantages

• Convenient synthesis
• Economic synthesis
• Relatively nontoxic materials involved


Innovation Details
 

Detailed Description

The invention describes a compound that has inhibitory effects comparable to state of the art cell cycle suppressing agents. The amyloid beta-induced toxicity that results in cell cycle re-entry in Alzheimer’s disease neurons is ameliorated significantly in the presence of this inhibitor. The effect is comparable to that of Roscovitine and Flavopiridol. This compound is expected to be relatively nontoxic and may be a potential alternative to the existing drugs for treating neurological disorders. It may also be useful, along with related versions, in the treatment of cancer and related pathologies.

File Number: 10MST019 

Other Information:

Patent Status: Provisional Patent Filed

Case Manager: Keith Strassner (kdstrass@mst.edu)


IP Protection


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This innovation currently is not available for online licensing. Please contact Keith Strassner at University of Missouri System: Missouri University of Science and Technology for more information.

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Case Manager:

Keith Strassner Keith Strassner

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February 11, 2009

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