A Technique for the Visualization and Quantification of Aqueous Humor Outflow in the Eye
University of Pittsburgh
posted on 01/19/2012
Investigators have developed a technique for the non-invasive visualization and quantification of the primary pathway of aqueous humor outflow in the human eye.
Suggested Uses
- Diagnosis of glaucoma
Advantages
- First known technique to provide non-invasive direct measurement of aqueous outflow in the primary outflow pathway in the human eye
Detailed Description
Volumetric circumferential scans of the limbus were obtained via SD-OCT (any scan containing structure and Doppler data will suffice). Scan data is then adjusted so that the gray scale presentation features outflow vessels as white structure on a dark background. A rolling ball background subtraction algorithm is then applied, and then contrast adjusted to isolate the outflow vessels. Individual processed volumes are stitched together to provide a perilimbal view of outflow structures. Terminal branches in the outflow vascular network are identified, and Doppler within those structures is measured. Doppler and cross-sectional assessments are combined to calculate flow in each terminal branch of the outflow network. Total aqueous humor outflow is determined by integrating flow across all identified terminal outflow structures.
Stage of Development
Software code written and successfully tested in vitro
Provisional Patent Application filed
File Number: 2476
This innovation currently is not available for online licensing. Please contact Brian Copple at University of Pittsburgh for more information.
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